Glp-1 And Glutamate Receptor Interaction In The Regulation Of Gut Motility

Glucagon-like peptide-1 (GLP-1) is a 30- or 31-amino-acid-long peptide hormone deriving from tissue-specific posttranslational processing of the proglucagon peptide.Glucagon-like peptide-1 receptor agonists gained approval as drugs to treat diabetes and obesity starting in the 2000s.

AI to Detect Gastric Lesions; GLP-1s and Gut Motility. In this installment of Sharmas Endoscopy Insights, I review a study examining the use of artificial intelligence for upper endoscopy and another investigating the effect of glucagon-like peptide-1 receptor agonists on gut motility.

Semaglutide activates GLP-1 receptors throughout the digestive tract, significantly reducing the rate at which food moves from the stomach into the small intestine and then through the rest of the GI system. This is actually part of how the medication promotes satiety.

In mouse models, GLP-1 receptor (GLP-1R) expression is observed in both the peripheral (pancreas, gastrointestinal tract, kidney, etc.) and CNS (hypothalamus, hippocampus, brainstem, etc.)4. The Influence of Gut Microbes and Their Metabolites in Food Intake Regulation.

Evidence for a role as a transmitter includes the presence of ionotropic glutamate receptors in nerve fibers and taste cells, as well as the expression of the glutamate transporter GLAST in Type I taste cells. However, the source and targets of glutamate in lingual tissue are unclear.

Diagram illustrating integrated regulation in physiology with neurons, astrocytes, and microglia interacting via insulin/IGF signaling, synaptic release of glutamate and GABA, and regulation of synaptic function, supported by a legend for key molecules and receptors.